Contributions of Antibiotic Penetration, Oxygen Limitation, and Low Metabolic Activity to Tolerance of Pseudomonas aeruginosa Biofilms to Ciprofloxacin and Tobramycin

The roles of slow antibiotic penetration, oxygen limitation, and low metabolic activity in the tolerance of Pseudomonas aeruginosa in biofilms to killing by antibiotics were investigated in vitro. Tobramycin and ciprofloxacin penetrated biofilms but failed to effectively kill the bacteria. Bacteria...

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Bibliographic Details
Main Authors: Walters, Marshall C., Roe, Frank, Bugnicourt, Amandine, Franklin, Michael J., Stewart, Philip S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC148957/
https://ncbi.nlm.nih.gov/pubmed/12499208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.1.317-323.2003
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