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Contributions of Antibiotic Penetration, Oxygen Limitation, and Low Metabolic Activity to Tolerance of Pseudomonas aeruginosa Biofilms to Ciprofloxacin and Tobramycin

The roles of slow antibiotic penetration, oxygen limitation, and low metabolic activity in the tolerance of Pseudomonas aeruginosa in biofilms to killing by antibiotics were investigated in vitro. Tobramycin and ciprofloxacin penetrated biofilms but failed to effectively kill the bacteria. Bacteria...

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Main Authors: Walters, Marshall C., Roe, Frank, Bugnicourt, Amandine, Franklin, Michael J., Stewart, Philip S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC148957/
https://ncbi.nlm.nih.gov/pubmed/12499208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.1.317-323.2003
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