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Defective Mitochondrial Gene Expression Results in Reactive Oxygen Species-Mediated Inhibition of Respiration and Reduction of Yeast Life Span

Mitochondrial dysfunction causes numerous human diseases and is widely believed to be involved in aging. However, mechanisms through which compromised mitochondrial gene expression elicits the reported variety of cellular defects remain unclear. The amino-terminal domain (ATD) of yeast mitochondrial...

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Detalhes bibliográficos
Main Authors: Bonawitz, Nicholas D., Rodeheffer, Matthew S., Shadel, Gerald S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489155/
https://ncbi.nlm.nih.gov/pubmed/16782871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02360-05
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