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Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis
In addition to its central role in cellular stress signaling, the tumor suppressor p53 modulates mitochondrial respiration through its nuclear transcription factor activity and localizes to mitochondria where it enhances apoptosis and suppresses mitochondrial DNA (mtDNA) mutagenesis. Here we demonst...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680458/ https://ncbi.nlm.nih.gov/pubmed/19413947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2009.01.004 |
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