Heparan Sulfate Proteoglycan Binding Properties of Adeno-Associated Virus Retargeting Mutants and Consequences for Their In Vivo Tropism

Adeno-associated virus type 2 (AAV-2) targeting vectors have been generated by insertion of ligand peptides into the viral capsid at amino acid position 587. This procedure ablates binding of heparan sulfate proteoglycan (HSPG), AAV-2's primary receptor, in some but not all mutants. Using an AA...

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Autori principali: Perabo, Luca, Goldnau, Daniela, White, Kathryn, Endell, Jan, Boucas, Jorge, Humme, Sibille, Work, Lorraine M., Janicki, Hanna, Hallek, Michael, Baker, Andrew H., Büning, Hildegard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489073/
https://ncbi.nlm.nih.gov/pubmed/16809332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00076-06
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