Heparan Sulfate Proteoglycan Binding Properties of Adeno-Associated Virus Retargeting Mutants and Consequences for Their In Vivo Tropism

Adeno-associated virus type 2 (AAV-2) targeting vectors have been generated by insertion of ligand peptides into the viral capsid at amino acid position 587. This procedure ablates binding of heparan sulfate proteoglycan (HSPG), AAV-2's primary receptor, in some but not all mutants. Using an AA...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Perabo, Luca, Goldnau, Daniela, White, Kathryn, Endell, Jan, Boucas, Jorge, Humme, Sibille, Work, Lorraine M., Janicki, Hanna, Hallek, Michael, Baker, Andrew H., Büning, Hildegard
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489073/
https://ncbi.nlm.nih.gov/pubmed/16809332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00076-06
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares