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Removal of Arginine 332 Allows Human TRIM5α To Bind Human Immunodeficiency Virus Capsids and To Restrict Infection
Human TRIM5α (TRIM5α(hu)) only modestly inhibits human immunodeficiency virus type 1 (HIV-1) and does not inhibit simian immunodeficiency virus (SIV(mac)). Alteration of arginine 332 in the TRIM5α(hu) B30.2 domain to proline, the residue found in rhesus monkey TRIM5α, has been shown to create a pote...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1489046/ https://ncbi.nlm.nih.gov/pubmed/16809279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00270-06 |
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