Mode of Transmission Affects the Sensitivity of Human Immunodeficiency Virus Type 1 to Restriction by Rhesus TRIM5α

Rhesus TRIM5α (rhTRIM5α), but not human TRIM5α (huTRIM5α), potently inhibits human immunodeficiency virus (HIV) infection and is thus a potentially valuable therapeutic tool. Primary human CD4 T cells engineered to express rhTRIM5α were highly resistant to cell-free HIV type 1 (HIV-1) infection. How...

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Detalhes bibliográficos
Main Authors: Richardson, Max W., Carroll, Richard G., Stremlau, Matthew, Korokhov, Nikolay, Humeau, Laurent M., Silvestri, Guido, Sodroski, Joseph, Riley, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573261/
https://ncbi.nlm.nih.gov/pubmed/18768965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01046-08
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