Persistent Transactivation by Meis1 Replaces Hox Function in Myeloid Leukemogenesis Models: Evidence for Co-Occupancy of Meis1-Pbx and Hox-Pbx Complexes on Promoters of Leukemia-Associated Genes

Homeobox transcription factors Meis1 and Hoxa9 promote hematopoietic progenitor self-renewal and cooperate to cause acute myeloid leukemia (AML). While Hoxa9 alone blocks the differentiation of nonleukemogenic myeloid cell-committed progenitors, coexpression with Meis1 is required for the production...

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Detalhes bibliográficos
Main Authors: Wang, Gang G., Pasillas, Martina P., Kamps, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1488994/
https://ncbi.nlm.nih.gov/pubmed/16648484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.10.3902-3916.2006
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