RNA Interference-Mediated Silencing of Mitotic Kinesin KIF14 Disrupts Cell Cycle Progression and Induces Cytokinesis Failure

KIF14 is a microtubule motor protein whose elevated expression is associated with poor-prognosis breast cancer. Here we demonstrate KIF14 accumulation in mitotic cells, where it associated with developing spindle poles and spindle microtubules. Cells at later stages of mitosis were characterized by...

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Detalhes bibliográficos
Main Authors: Carleton, Michael, Mao, Mao, Biery, Matthew, Warrener, Paul, Kim, Sammy, Buser, Carolyn, Marshall, C. Gary, Fernandes, Christine, Annis, James, Linsley, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1488988/
https://ncbi.nlm.nih.gov/pubmed/16648480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.10.3853-3863.2006
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