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Synergistic Transcriptional Activation of Indoleamine Dioxygenase by IFN-γ and Tumor Necrosis Factor-α

Interferon-γ (IFN-γ)-induced indoleamine 2,3-dioxygenase (IDO) activity inhibits the growth of susceptible intracellular pathogens by catalyzing the oxidative cleavage of the indole ring of l-tryptophan and depleting pools of the essential amino acid. Tumor necrosis factor-α (TNF-α) synergistically...

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Bibliografiska uppgifter
Huvudupphovsmän: ROBINSON, CORY M., SHIREY, KARI ANN, CARLIN, JOSEPH M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2003
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1488822/
https://ncbi.nlm.nih.gov/pubmed/13678429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/107999003322277829
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