The Zinc-Dependent Major Histocompatibility Complex Class II Binding Site of Streptococcal Pyrogenic Exotoxin C Is Critical for Maximal Superantigen Function and Toxic Activity

The cocrystal structure of streptococcal pyrogenic exotoxin C (SPE C) with HLA-DR2a (DRA*0101,DRB5*0101) revealed a zinc-dependent interaction site through residues 167, 201, and 203 on SPE C and residue 81 on the β-chain of HLA-DR2a (DRA*0101,DRB5*0101). Mutation of these SPE C residues resulted in...

Ful tanımlama

Detaylı Bibliyografya

Yayımlandı:	Infect Immun
Asıl Yazarlar:	Tripp, Timothy J., McCormick, John K., Webb, Jennifer M., Schlievert, Patrick M.
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Microbiology (ASM) 2003
Konular:	Molecular Pathogenesis
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148863/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12595474/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.3.1548-1550.2003
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!