The Zinc-Dependent Major Histocompatibility Complex Class II Binding Site of Streptococcal Pyrogenic Exotoxin C Is Critical for Maximal Superantigen Function and Toxic Activity

The cocrystal structure of streptococcal pyrogenic exotoxin C (SPE C) with HLA-DR2a (DRA*0101,DRB5*0101) revealed a zinc-dependent interaction site through residues 167, 201, and 203 on SPE C and residue 81 on the β-chain of HLA-DR2a (DRA*0101,DRB5*0101). Mutation of these SPE C residues resulted in...

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Detalhes bibliográficos
Main Authors: Tripp, Timothy J., McCormick, John K., Webb, Jennifer M., Schlievert, Patrick M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC148863/
https://ncbi.nlm.nih.gov/pubmed/12595474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.3.1548-1550.2003
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