The Zinc-Dependent Major Histocompatibility Complex Class II Binding Site of Streptococcal Pyrogenic Exotoxin C Is Critical for Maximal Superantigen Function and Toxic Activity

The cocrystal structure of streptococcal pyrogenic exotoxin C (SPE C) with HLA-DR2a (DRA*0101,DRB5*0101) revealed a zinc-dependent interaction site through residues 167, 201, and 203 on SPE C and residue 81 on the β-chain of HLA-DR2a (DRA*0101,DRB5*0101). Mutation of these SPE C residues resulted in...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Tripp, Timothy J., McCormick, John K., Webb, Jennifer M., Schlievert, Patrick M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Molecular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148863/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12595474/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.3.1548-1550.2003
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