Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding.

We show that WRN helicase contains a unique 5'-->3' exonuclease activity in the N-terminal region. Adeletion mutant lacking 231 N-terminal amino acid residues, made in a baculovirus system, did nothave this activity, while it showed ATPase and DNA helicase activities. This exonuclease activity was c...

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Publicado en:	Nucleic Acids Res
Autores principales:	Suzuki, N, Shiratori, M, Goto, M, Furuichi, Y
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 1999
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148803/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10325426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.11.2361
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