Chiral and steric effects in the efficient binding of alpha-anomeric deoxyoligonucleoside N-alkylphosphoramidates to ssDNA and RNA.

We report hybridization properties of new phosphate-modified alpha-oligonucleoside analogs with non-ionic or cationic internucleotide linkages such as methoxy-ethylphosphoramidate (PNHME), phosphoromorpholi-date (PMOR) and dimethylaminopropylphosphor-amidate (PNHDMAP). First we evaluated the chirali...

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Bibliographic Details

Published in:	Nucleic Acids Res
Main Authors:	Laurent, A, Naval, M, Debart, F, Vasseur, J J, Rayner, B
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 1999
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148688/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10518605/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.21.4151
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