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Rearrangements of Human Mitochondrial DNA (mtDNA): New Insights into the Regulation of mtDNA Copy Number and Gene Expression

Mitochondria from patients with Kearns–Sayre syndrome harboring large-scale rearrangements of human mitochondrial DNA (mtDNA; both partial deletions and a partial duplication) were introduced into human cells lacking endogenous mtDNA. Cytoplasmic hybrids containing 100% wild-type mtDNA, 100% mtDNA w...

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Main Authors: Tang, Yingying, Schon, Eric A., Wilichowski, Ekkehard, Vazquez-Memije, Martel E., Davidson, Edgar, King, Michael P.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2000
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC14860/
https://ncbi.nlm.nih.gov/pubmed/10749943
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