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Cytosine methylation transforms an E2F site in the retinoblastoma gene promoter into a binding site for the general repressor methylcytosine-binding protein 2 (MeCP2).

The CpG-rich promoter of the retinoblastoma tumor suppressor gene (Rb-1) is normally unmethylated. However, aberrant methylation of CpG dinucleotides within the Rb-1 promoter has been depicted in certain tumors, which determines transcriptional inactivity of the gene and absence of the pRb retinobla...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Di Fiore, B, Palena, A, Felsani, A, Palitti, F, Caruso, M, Lavia, P
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1999
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC148498/
https://ncbi.nlm.nih.gov/pubmed/10390525
Etiketak: Etiketa erantsi
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