Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA.

Vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR play important roles in physiological and pathological angiogenesis. Ribozymes that target the VEGF receptor mRNAs were developed and their biological activities in cell culture and an animal model were assessed. Ribozymes tar...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Parry, T J, Cushman, C, Gallegos, A M, Agrawal, A B, Richardson, M, Andrews, L E, Maloney, L, Mokler, V R, Wincott, F E, Pavco, P A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1999
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148463/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10373571/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.13.2569
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