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The potential role of ribosomal frameshifting in generating aberrant proteins implicated in neurodegenerative diseases
Aberrant forms of proteins ubiquitin B and β-amyloid precusor protein, UBB(+1) and APP(+1), are implicated in human neurodegenerative diseases. They have their carboxyl-terminal regions derived from an alternative reading frame. Transcription slippage has been invoked to explain the production of th...
Uloženo v:
| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2006
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1484430/ https://ncbi.nlm.nih.gov/pubmed/16714280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.84406 |
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