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The potential role of ribosomal frameshifting in generating aberrant proteins implicated in neurodegenerative diseases

Aberrant forms of proteins ubiquitin B and β-amyloid precusor protein, UBB(+1) and APP(+1), are implicated in human neurodegenerative diseases. They have their carboxyl-terminal regions derived from an alternative reading frame. Transcription slippage has been invoked to explain the production of th...

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Detalhes bibliográficos
Main Authors: Wills, Norma M., Atkins, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1484430/
https://ncbi.nlm.nih.gov/pubmed/16714280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.84406
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