Specific reverse transcriptase slippage at the HIV ribosomal frameshift sequence: potential implications for modulation of GagPol synthesis

Synthesis of HIV GagPol involves a proportion of ribosomes translating a U6A shift site at the distal end of the gag gene performing a programmed -1 ribosomal frameshift event to enter the overlapping pol gene. In vitro studies here show that at the same shift motif HIV reverse transcriptase generat...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Penno, Christophe, Kumari, Romika, Baranov, Pavel V., van Sinderen, Douwe, Atkins, John F.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
Assuntos:
Molecular Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737442/
https://ncbi.nlm.nih.gov/pubmed/28973470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx690
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