CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2

It is thought that the H19 imprinting control region (ICR) directs the silencing of the maternally inherited Igf2 allele through a CTCF-dependent chromatin insulator. The ICR has been shown to interact physically with a silencer region in Igf2, differentially methylated region (DMR)1, but the role o...

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Hauptverfasser: Kurukuti, Sreenivasulu, Tiwari, Vijay Kumar, Tavoosidana, Gholamreza, Pugacheva, Elena, Murrell, Adele, Zhao, Zhihu, Lobanenkov, Victor, Reik, Wolf, Ohlsson, Rolf
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1484419/
https://ncbi.nlm.nih.gov/pubmed/16815976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600326103
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