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Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival

Chronic engagement of the B cell receptor by soluble autoantigen leads to reduced B cell survival. Using the Ig and hen egg lysozyme double transgenic mouse model, we demonstrate that the survival of soluble autoantigen-engaged B cells is further reduced in mice lacking CD4 T cells or deficient in C...

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Bibliografiske detaljer
Main Authors: Lesley, Robin, Kelly, Lisa M., Xu, Ying, Cyster, Jason G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1484418/
https://ncbi.nlm.nih.gov/pubmed/16815973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601539103
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