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Leishmania mexicana Mutants Lacking Glycosylphosphatidylinositol (GPI):Protein Transamidase Provide Insights into the Biosynthesis and Functions of GPI-anchored Proteins

The major surface proteins of the parasitic protozoon Leishmania mexicana are anchored to the plasma membrane by glycosylphosphatidylinositol (GPI) anchors. We have cloned the L. mexicana GPI8 gene that encodes the catalytic component of the GPI:protein transamidase complex that adds GPI anchors to...

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Autori principali: Hilley, James D., Zawadzki, Jody L., McConville, Malcolm J., Coombs, Graham H., Mottram, Jeremy C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC14840/
https://ncbi.nlm.nih.gov/pubmed/10749923
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