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5-(1-propargylamino)-2'-deoxyuridine (UP): a novel thymidine analogue for generating DNA triplexes with increased stability.

We have used quantitative DNase I footprinting and UV-melting studies to examine the formation of DNA triplexes in which the third strand thymines have been replaced by 5-propargylamino-dU (UP). The intra-molecular triplex A6-L-T6-L-(UP)5T (L = two octanediol residues) shows a single UV-melting tran...

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Détails bibliographiques
Auteurs principaux: Bijapur, J, Keppler, M D, Bergqvist, S, Brown, T, Fox, K R
Format: Artigo
Langue:Inglês
Publié: 1999
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC148387/
https://ncbi.nlm.nih.gov/pubmed/10101187
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