Barminomycin forms GC-specific adducts and virtual interstrand crosslinks with DNA.

The sequence specificity of the binding of barminomycin (SN-07 chromophore) to DNA was investigated using an in vitro transcription assay. It was found that this compound formed blockages to transcription, and these blocks were highly selective for 5'-GC sequences. The half-lives of the first seven...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Perrin, L C, Cullinane, C, Kimura, K, Phillips, D R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1999
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148384/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10101184/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.8.1781
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