Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers

BACKGROUND: The MDM2 gene encodes a negative regulator of the p53 tumour suppressor protein. A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been reported to produce accelerated tumour formation in individuals with inherited p53 mutations. We hav...

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Main Authors: Copson, Ellen R, White, Helen E, Blaydes, Jeremy P, Robinson, David O, Johnson, Peter W, Eccles, Diana M
格式: Artigo
語言:Inglês
出版: BioMed Central 2006
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483833/
https://ncbi.nlm.nih.gov/pubmed/16563154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-80
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