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Oligonucleotide-europium complex conjugate designed to cleave the 5' cap structure of the ICAM-1 transcript potentiates antisense activity in cells.

The 5' cap structure of mRNA is a N7 methylated guanosine residue that is linked by a 5'-5' triphosphate linkage to the 5'-terminus of cellular and viral RNAs synthesized by RNA polymerase II. This unique structure facilitates several processes of mRNA metabolism, including splicing, nucleocytoplasm...

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Udgivet i:Nucleic Acids Res
Principais autores: Baker, B F, Lot, S S, Kringel, J, Cheng-Flournoy, S, Villiet, P, Sasmor, H M, Siwkowski, A M, Chappell, L L, Morrow, J R
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1999
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148351/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10037819/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.6.1547
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