Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route

Antisense oligonucleotides (ASOs) are promising therapeutics for intractable central nervous system (CNS) diseases. For this clinical application, neurotoxicity is one of the critical limitations. Therefore, an evaluation of this neurotoxicity from a behavioral perspective is important to reveal sym...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Chunyan Jia, Su Su Lei Mon, Ying Yang, Maho Katsuyama, Kie Yoshida-Tanaka, Tetsuya Nagata, Kotaro Yoshioka, Takanori Yokota
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2023-03-01
Σειρά:	Molecular Therapy: Nucleic Acids
Θέματα:	MT: Oligonucleotides: Therapies and Applications antisense oligonucleotide intracerebroventricular injection acute neurotoxicity central nervous system disease calcium homeostasis
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S2162253122003316
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