Cód QR

Favorable efficacy and reduced acute neurotoxicity by antisense oligonucleotides with 2′,4′-BNA/LNA with 9-(aminoethoxy)phenoxazine

An increasing number of antisense oligonucleotides (ASOs) have been approved for clinical use. However, improvements of both efficacy and safety in the central nervous system (CNS) are crucial for the treatment with CNS diseases. We aimed to overcome the crucial issues by our development of various...

Cur síos iomlán

Sábháilte in:
Príomhchruthaitheoirí: Taiki Matsubayashi, Kotaro Yoshioka, Su Su Lei Mon, Maho Katsuyama, Chunyan Jia, Takao Yamaguchi, Rintaro Iwata Hara, Tetsuya Nagata, Osamu Nakagawa, Satoshi Obika, Takanori Yokota
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2024-06-01
Sraith:Molecular Therapy: Nucleic Acids
Ábhair:
MT: Oligonucleotides: Therapies and Applications
2′,4′-BNA/LNA with 9-aminoethoxyphenoxazine
acute CNS toxicity
antisense oligonucleotide
central nervous system disease
gene silencing effect
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2162253124000489
Clibeanna: Cuir clib leis
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!

Míreanna comhchosúla