The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors

BRCA1 and BRCA2 mutations are responsible for most familial breast carcinomas. Recent reports carried out in non-cancerous mouse BRCA1- or BRCA2-deficient embryonic stem (ES) cells, and hamster BRCA2-deficient cells have demonstrated that the targeted inhibition of poly(ADP-ribose) polymerase (PARP-...

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Bibliographic Details
Main Authors: De Soto, Joseph A., Wang, Xianyan, Tominaga, Yohei, Wang, Rui-Hong, Cao, Liu, Qiao, Wenhui, Li, Cuiling, Xu, Xiaoling, Skoumbourdis, Amanda P., Prindiville, Sheila A., Thomas, Craig J., Deng, Chu-Xia
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2006
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483123/
https://ncbi.nlm.nih.gov/pubmed/16810332
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