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Mechanism of Titin Unfolding by Force: Insight from Quasi-Equilibrium Molecular Dynamics Calculations

We have studied the unfolding by force of one of the immunoglobulin domains of the muscle protein titin using molecular dynamics simulations at 300 K. Previous studies, done at constant pulling rates, showed that under the effect of the force two strands connected to each other by six backbone H-bon...

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Detalles Bibliográficos
Main Authors: Pabón, Germán, Amzel, L. Mario
Formato: Artigo
Idioma:Inglês
Publicado: Biophysical Society 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483073/
https://ncbi.nlm.nih.gov/pubmed/16632514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.082594
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