Forced Dimerization of gp130 Leads to Constitutive STAT3 Activation, Cytokine-independent Growth, and Blockade of Differentiation of Embryonic Stem Cells

The mode of activation of glycoprotein 130 kDa (gp130) and the transmission of the activation status through the plasma membrane are incompletely understood. In particular, the molecular function of the three juxtamembrane fibronectin III-like domains of gp130 in signal transmission remains unclear....

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Hlavní autoři: Stuhlmann-Laeisz, Christiane, Lang, Sigrid, Chalaris, Athena, Krzysztof, Paliga, Enge, Sudarman, Eichler, Jutta, Klingmüller, Ursula, Samuel, Michael, Ernst, Matthias, Rose-John, Stefan, Scheller, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483035/
https://ncbi.nlm.nih.gov/pubmed/16624864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-12-1129
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