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Role for Tandem Duplication and Lon Protease in AcrAB-TolC- Dependent Multiple Antibiotic Resistance (Mar) in an Escherichia coli Mutant without Mutations in marRAB or acrRAB

A spontaneous mutant (M113) of Escherichia coli AG100 with an unstable multiple antibiotic resistance (Mar) phenotype was isolated in the presence of tetracycline. Two mutations were found: an insertion in the promoter of lon (lon3::IS186) that occurred first and a subsequent large tandem duplicatio...

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Detalhes bibliográficos
Main Authors: Nicoloff, Hervé, Perreten, Vincent, McMurry, Laura M., Levy, Stuart B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482967/
https://ncbi.nlm.nih.gov/pubmed/16740948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01502-05
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