Death-receptor activation halts clathrin-dependent endocytosis

Endocytosis is crucial for various aspects of cell homeostasis. Here, we show that proapoptotic death receptors (DRs) trigger selective destruction of the clathrin-dependent endocytosis machinery. DR stimulation induced rapid, caspase-mediated cleavage of key clathrin-pathway components, halting cel...

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Main Authors: Austin, Cary D., Lawrence, David A., Peden, Andrew A., Varfolomeev, Eugene E., Totpal, Klara, De Mazière, Ann M., Klumperman, Judith, Arnott, David, Pham, Victoria, Scheller, Richard H., Ashkenazi, Avi
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482799/
https://ncbi.nlm.nih.gov/pubmed/16801533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604044103
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