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Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity
Accumulation of abnormally hyperphosphorylated tau (P-tau) in the form of tangles of paired helical filaments and/or straight filaments is one of the hallmarks of Alzheimer's disease (AD) and other tauopathies. P-tau is also found unpolymerized in AD. Although the cognitive decline is known to...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1482669/ https://ncbi.nlm.nih.gov/pubmed/16735465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603214103 |
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