Foxp3(+) CD25(+) regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

Thymus-derived regulatory T cells (Tregs) expressing CD4, CD25, and the transcription factor Foxp3 play major roles in preventing autoimmunity. The Treg population is enriched in T cells expressing high-avidity self-reactive T cell receptors, and thymic epithelial cells expressing self-antigens (Ag)...

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Bibliographic Details
Main Authors: Cabarrocas, Julie, Cassan, Cécile, Magnusson, Fay, Piaggio, Eliane, Mars, Lennart, Derbinski, Jens, Kyewski, Bruno, Gross, David-Alexandre, Salomon, Benoit L., Khazaie, Khashayarsha, Saoudi, Abdelhadi, Liblau, Roland S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482513/
https://ncbi.nlm.nih.gov/pubmed/16709665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603086103
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