Radiation down-regulates replication origin activity throughout the S phase in mammalian cells.

An asynchronous culture of mammalian cells responds acutely to ionizing radiation by inhibiting the overall rate of DNA replication by approximately 50% for a period of several hours, presumably to allow time to repair DNA damage. At low and moderate doses, this S phase damage-sensing (SDS) pathway...

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Main Authors: Larner, J M, Lee, H, Little, R D, Dijkwel, P A, Schildkraut, C L, Hamlin, J L
Formato: Artigo
Idioma:Inglês
Publicado: 1999
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC148250/
https://ncbi.nlm.nih.gov/pubmed/9889276
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