The Dihydrofolate Reductase Origin of Replication Does Not Contain Any Nonredundant Genetic Elements Required for Origin Activity

The Chinese hamster dihydrofolate reductase (DHFR) origin of replication consists of a broad zone of potential initiation sites scattered throughout a 55-kb intergenic spacer, with at least three sites being preferred (ori-β, ori-β′, and ori-γ). We previously showed that deletion of the most active...

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Detalhes bibliográficos
Main Authors: Mesner, L. D., Li, X., Dijkwel, P. A., Hamlin, J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140713/
https://ncbi.nlm.nih.gov/pubmed/12529386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.3.804-814.2003
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