The Dihydrofolate Reductase Origin of Replication Does Not Contain Any Nonredundant Genetic Elements Required for Origin Activity

The Chinese hamster dihydrofolate reductase (DHFR) origin of replication consists of a broad zone of potential initiation sites scattered throughout a 55-kb intergenic spacer, with at least three sites being preferred (ori-β, ori-β′, and ori-γ). We previously showed that deletion of the most active...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Mesner, L. D., Li, X., Dijkwel, P. A., Hamlin, J. L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	DNA Dynamics and Chromosome Structure
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140713/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12529386/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.3.804-814.2003
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