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Functional analysis of human MutSalpha and MutSbeta complexes in yeast.

Mismatch repair (MMR) is initiated when a heterodimer of hMSH2*hMSH6 or hMSH2*hMSH3 binds to mismatches. Here we perform functional analyses of these human protein complexes in yeast. We use a sensitive genetic system wherein the rate of single-base deletions in a homopolymeric run in the LYS2 gene...

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Udgivet i:Nucleic Acids Res
Principais autores: Clark, A B, Cook, M E, Tran, H T, Gordenin, D A, Resnick, M A, Kunkel, T A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1999
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148241/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9889267/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.3.736
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