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Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine.

Oxidative damage to DNA bases commonly resultsin the formation of oxidized purines, particularly 7,8-dihydro-8-oxoguanine (8-oxoG) and 7,8-dihydro-8-oxoadenine (8-oxoA), the former being a well-known mutagenic lesion. Since 8-oxoG is readily subject to further oxidation compared with normal bases, t...

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Библиографические подробности
Главные авторы: Duarte, V, Muller, J G, Burrows, C J
Формат: Artigo
Язык:Inglês
Опубликовано: 1999
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC148206/
https://ncbi.nlm.nih.gov/pubmed/9862971
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