Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine.

Oxidative damage to DNA bases commonly resultsin the formation of oxidized purines, particularly 7,8-dihydro-8-oxoguanine (8-oxoG) and 7,8-dihydro-8-oxoadenine (8-oxoA), the former being a well-known mutagenic lesion. Since 8-oxoG is readily subject to further oxidation compared with normal bases, t...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Duarte, V, Muller, J G, Burrows, C J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1999
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148206/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9862971/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.2.496
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