Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities

ALS2 is an autosomal recessive form of spastic paraparesis (motor neuron disease) with juvenile onset and slow progression caused by loss of function of alsin, an activator of Rac1 and Rab5 small GTPases. To establish an animal model of ALS2 and derive insights into the pathogenesis of this illness,...

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Autors principals: Devon, R. S., Orban, P. C., Gerrow, K., Barbieri, M. A., Schwab, C., Cao, L. P., Helm, J. R., Bissada, N., Cruz-Aguado, R., Davidson, T.-L., Witmer, J., Metzler, M., Lam, C. K., Tetzlaff, W., Simpson, E. M., McCaffery, J. M., El-Husseini, A. E., Leavitt, B. R., Hayden, M. R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480452/
https://ncbi.nlm.nih.gov/pubmed/16769894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510197103
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