Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities

ALS2 is an autosomal recessive form of spastic paraparesis (motor neuron disease) with juvenile onset and slow progression caused by loss of function of alsin, an activator of Rac1 and Rab5 small GTPases. To establish an animal model of ALS2 and derive insights into the pathogenesis of this illness,...

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Detalhes bibliográficos
Main Authors: Devon, R. S., Orban, P. C., Gerrow, K., Barbieri, M. A., Schwab, C., Cao, L. P., Helm, J. R., Bissada, N., Cruz-Aguado, R., Davidson, T.-L., Witmer, J., Metzler, M., Lam, C. K., Tetzlaff, W., Simpson, E. M., McCaffery, J. M., El-Husseini, A. E., Leavitt, B. R., Hayden, M. R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480452/
https://ncbi.nlm.nih.gov/pubmed/16769894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510197103
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