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Synthetic Studies on the Bryostatins: Synthetic Routes to Analogues Containing the Tricyclic Macrolactone Core

[Image: see text] Synthesis of the first of a projected series of bryostatin analogues has been accomplished in 26 steps and 2.2% overall yield. In this letter, we detail two approaches to the structural core of these tricyclic macrolactone bryostatin analogues. The key features of the route include...

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Autori principali: Keck, Gary E., Truong, Anh P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480407/
https://ncbi.nlm.nih.gov/pubmed/15901157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol050512o
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