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Unwinding of origin-specific structures by human replication protein A occurs in a two-step process.

The simian virus 40 (SV40) large tumor antigen(T antigen) has been shown to induce the melting of 8 bp within the SV40 origin of replication. We found previously that a 'pseudo-origin' DNA molecule (PO-8) containing a central 8 nt single-stranded DNA (ssDNA) bubble was efficiently bound an...

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Bibliografische gegevens
Hoofdauteurs: Iftode, C, Borowiec, J A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1998
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC148024/
https://ncbi.nlm.nih.gov/pubmed/9837994
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