Unwinding of origin-specific structures by human replication protein A occurs in a two-step process.
The simian virus 40 (SV40) large tumor antigen(T antigen) has been shown to induce the melting of 8 bp within the SV40 origin of replication. We found previously that a 'pseudo-origin' DNA molecule (PO-8) containing a central 8 nt single-stranded DNA (ssDNA) bubble was efficiently bound and denature...
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| Veröffentlicht in: | Nucleic Acids Res |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
1998
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9837994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.24.5636 |
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