Modified (PNA, 2'-O-methyl and phosphoramidate) anti-TAR antisense oligonucleotides as strong and specific inhibitors of in vitro HIV-1 reverse transcription.

Natural beta-phosphodiester 16mer and 15mer antisense oligonucleotides targeted against the HIV-1 and HIV-2 TAR RNAs respectively were previously described as sequence-specific inhibitors of in vitro retroviral reverse transcription. In this work, we tested chemically modified oligonucleotide analog...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Boulmé, F, Freund, F, Moreau, S, Nielsen, P E, Gryaznov, S, Toulmé, J J, Litvak, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148009/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826777/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.23.5492
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