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Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation

The heterodimeric transcription factor HIF (hypoxia-inducible factor) is central to the regulation of gene expression by oxygen. Three oxygen-dependent prolyl hydroxylase enzymes [PHD1 (prolyl hydroxylase domain 1), PHD2 and PHD3] control the abundance of HIF. In the presence of oxygen, they hydroxy...

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Bibliografske podrobnosti
Main Authors: Tian, Ya-Min, Mole, David R., Ratcliffe, Peter J., Gleadle, Jonathan M.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479752/
https://ncbi.nlm.nih.gov/pubmed/16509823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051996
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