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INSM1 functions as a transcriptional repressor of the neuroD/β2 gene through the recruitment of cyclin D1 and histone deacetylases

INSM1/IA-1 (insulinoma-associated 1) is a developmentally regulated zinc-finger transcription factor, exclusively expressed in the foetal pancreas and nervous system, and in tumours of neuroendocrine origin. We have identified an INSM1 binding site in the neuroD/β2 promoter and demonstrated transcri...

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Bibliografiske detaljer
Main Authors: Liu, Wei-Dong, Wang, Hong-Wei, Muguira, Michelle, Breslin, Mary B., Lan, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479746/
https://ncbi.nlm.nih.gov/pubmed/16569215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051669
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